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Use of CT, MRI, & Localized 1H MR Spectroscopy in Canavan's Disease:A Case Report Ann Neurol 30:106-110, Marks,H.G.,et al, 1991 See this aricle in Pubmed Article Abstract The neurological evaluation of Canavan's disease in a 38-month old girl is discussed.Computed tomography showed diffuse symmetrical low attenuation values of the subcortical and deep cerebral white matter.Magnetic resonance imaging demonstrated symmetrical diffuse low signal intensity on T1-weighted images and high signal intensity on T2-weighted images.With the use of 1H magnetic resonance spectroscopy,we were able to show elevated levels of N-acetylaspartic acid in the occipital lobe of our patient.The in vivo measurement of N-acetylaspartic acid in the brain by 1H magnetic resonance spectroscopy offers an additional noninvasive diagnostic test for establishing the diagnosis of Canavan's disease.With the increasing availability of magnetic resonance spectroscopy,clinicians may be able to confirm the diagnosis of Canavan's disease immediately after magnetic resonance imaging reveals the typical abnormal-ties of the white matter.

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